So far this year, 1,855 positive cases have been recorded, with more than 80 percent of the people up to date on their whooping cough shots.
In a series of investigative articles in 2010, inewsource and KPBS first revealed a high rate of vaccine failure. Researchers now agree the whooping cough vaccine used today is not as effective as the vaccine used almost 20 years ago.
Their research used baboons, considered the most human-like model for studying whooping cough. Baboons at ages 2, 4 and 6 months were vaccinated and then exposed to whooping cough at 7 months — when vaccine protection would be new and strong... The baboons didn't get sick, but they had high levels of bacteria in their respiratory system for five weeks — which suggest they were contagious for about that long. Some baboons given the old vaccine had low levels after only two weeks.
That's a big deal finding because it was thought that people only spread the disease when they had coughs and other symptoms, said Dr. Erik Hewlett, a University of Virginia whooping cough researcher who was not involved in the FDA study but has collaborated with Merkel... Health officials have sought to protect small children by vaccinating the people who are in contact with them such as grandparents and baby sitters — a strategy called "cocooning." But that may not work as well as hoped if infected people who don't show any symptoms can still spread it, the research suggests.
Unvaccinated children are supposedly the cause, according to state health officials, of a recent whooping cough outbreak that occurred in the posh Cape Cod area of Massachusetts. But as reported by CBS Boston, all of the children affected by the outbreak were already vaccinated, proving once again that vaccines don’t really work.
We show that the UK outbreak was polyclonal in nature, caused by multiple distinct but closely related strains. Importantly, we demonstrate that acellular vaccine antigen encoding genes are evolving at higher rates than other surface protein encoding genes. This was true even prior to the introduction of pertussis vaccines, but has become more pronounced since the introduction of the current acellular vaccines. The fast evolution of vaccine antigen genes has serious consequences for the ability of current vaccines to continue to control pertussis.
Despite most being fully vaccinated for whooping cough, the infection is still present in about a fifth of UK children visiting their doctor with a persistent cough.
Acellular pertussis vaccines do not control pertussis. A new approach to offer protection to infants is necessary. BPZE1, a genetically modified Bordetella pertussis strain, was developed as a live attenuated nasal pertussis vaccine by genetically eliminating or detoxifying 3 toxins.
The observation that aP (acellular pertussis vaccines), which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccines
The characteristics of this resurgence changed dramatically in 2005, and the greatest number of reported cases since ~1960 occurred in 2012. There are five possible reasons for the resurgence: 1) genetic changes in B. pertussis; 2) a decrease in vaccine efficacy; 3) a more rapid occurrence of waning immunity; 4) increased recognition and reporting of pertussis; and 5) newer laboratory diagnostic tests
Tdap vaccination was moderately effective (53.0%) at preventing PCR confirmed pertussis among adolescents and adults
The findings, from a large case-control study, add to the growing evidence of shortcomings of the newer acellular vaccines
Our data suggests that the current schedule of acellular pertussis vaccine doses is insufficient to prevent outbreaks of pertussis
Parents across Australia will no longer receive free whooping cough vaccinations because it is not effective in protecting newborns from the potentially deadly illness, a parliamentary committee has heard
Despite this vaccine being hugely effective against B. pertussis, which was once the primary childhood killer, these data suggest that the vaccine may be contributing to the observed rise in whooping cough incidence over the last decade by promoting B. parapertussis infection