It is well established that vaccines can cause encephalopathy, that fact is made clear by the tabled injury by the Health and Human Services (HRSA). A slow viral encephalopathy is also demonstrated by the evaluation of of the cerebral spinal fluid in children who regressed into autism after the MMR vaccine. The patented measles virus was found in the fluid along with an uptake of proinflammatory cytokines, which demonstrate the condition.
Excerpt from the study: "Autistic encephalopathy is a complex disorder in which there is clearly more than one potential mechanism for regression. Cofactors including genetic predisposition are likely to influence the presentation and timing of symptom development. The potential mechanisms of AE (adverse events) in these children include, but are not limited to, some or all of the following: a toxic gut-brain interaction such as occurs in hepatic encephalopathy; immunological disruption of central nervous system functions; and direct viral invasion of the brain" (Bradstreet et al, 2004).
Mitochondriopathy Cause Or Effect From Vaccination
The "dysfunctional mitochondria" can cause autism as they are producing more damaging free radicals than normal mitochondria. Mitochondria made toxic by chemical compounds like heavy metals (ethylmercury) would do the same thing as the tightest binding site in mercury in the body is in the "iron sulfur centers" (Fe-S) of the electron transport chain that carries the 'electron' used normally to produce the mitochondrial pH gradient that makes energy in the form of ATP. Heavy metals blocking of this polypeptide chain leads to the production of hydroxyl free radicals by release of the electron to react with water. This causes oxidative stress and low reduction glutathione levels as observed in autism and many neurological illnesses. A recent cadaver study of autistic brains in comparison with non-autistic brains shows this decrease in glutathione, increase in brain inflammation (encephalopathy), and oxidative damage in patients with autism.
Excerpt from study: "Together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage" (Rose et al, 2012).
Another vaccine ingredient, aluminum adjutants has also demonstrated negative impacts on the mitochondria.
Excerpt from study: "While the [Al3+] is vanishingly low at neutral pH, the trihydroxide is the major form and should be considered as an important candidate for aluminum-induced cellular effects" (Zhang et al, 1989).
In further reading about AL you will find the same interplay between the iron sulfur centers (FE-S) as seen with mercury.
Excerpt from study: "And Complex I and III might be the source of Al-induced mitochondrial reactive oxygen species (ROS) through interaction between Al and iron-sulfur (Fe-S) protein" (Li Z et al, 2010).
The case of Hannah Poling where her underlying mitochondrial disorder exacerbated by a vaccine induced fever cascaded into the diagnosis of autism is a well-established consequence. But this mitochondriopathy process could also be caused by the vaccines and or other toxins themselves. An interesting scientific publication demonstrates that autistics with mitochondrial dysfunction (MD) do not have the genetic mutation to explain the MD. Again in this study we find interplays with glutathione, and fatty-acid oxidation pathways etc being biomarkers in the pathophysiology of autism.
Excerpt from study: "Acquired MD has been demonstrated in a rodent ASD model in which propionic acid (PPA), an enteric bacterial fermentation product of ASD-associated gut bacteria, is infused intracerebroventricularly. This animal model shows validity as it demonstrates many behavioral, metabolic, neuropathologic and neurophysiologic abnormalities associated with ASD" (Frye et al, 2013).
The toxic environmental exposures found in organophosphates, heavy metals, and yes even ingredients found in vaccinations can either exacerbate an underlying MD or cause said disorder leading to the symptomology of autism spectrum disorder or other negative neurological condition. We do know from a recent study that children with autism have higher levels of toxic compounds in their blood. This is a clear indicator that this subpopulation has a difficult time excreting these exposures than in the neuro-typical population.
Excerpt from study: "Overall, children with autism have higher average levels of several toxic metals, and levels of several toxic metals are strongly associated with variations in the severity of autism for all three of the autism severity scales investigated" (Adams et al, 2013).
Majority Of Vaccinated Seeming No Acute Harm
In other words the dose make the poison. This is true in some circumstances but when you have a subpopulation that is genetically susceptible to inadequate toxicity excretion, which thereby disrupts cellular function leading to a whole host of neuro/immunological disorders the cascade of injury is plausible. I would never claim that vaccines are the only contributor to autism but the accessibility, mechanism, ingredients, and disorder occurrence in time make them a likely contributor to at least some autism diagnosis. I would also like to say the long term affects of vaccination is largely unknown. I have read multiple studies and surveys looking at the health of patients who are vaccinated vs those not vaccinated. The population not vaccinated is much healthier in all categories. In another study looking at the trends of mortality and hospitalizations when comparing vaccine status you find the more vaccines a child received the more likely they will be hospitalized or die.
Excerpt from study: "Our finding show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths" (Goldman et al, 2012).
So I question the idea of waving away the idea of acute, and long-term harm by vaccination simply because the majority seemingly are spared injury.
Hepatotoxicity or Neuroexcitotoxicity
If the exposure to vaccine chemical agents disrupts cellular function in the brain as demonstrated above it would not necessary create hepatotoxicity. This is well known in the study of cellular pathology regarding direct and indirect toxic exposure. Various drugs affect various organs, the clinical presentations vary considerably. As shown in the study, which showed "children with autism have higher average levels of several toxic metals...." were not suffering from hepatotoxicity (Adams et al, 2013). So to simply write off any association of vaccine toxic exposure because there is a lack of evidence in liver toxicity is a fallacy. You are in the same occurrence thereby writing off any environmental toxin because the liver is more or less unaffected. We do know that there is a toxic environmental contribution so the argument falls apart.
Wakefield Once Again
It is so tiring to constantly correct the events surrounding this physicians research. His work has little consequence to the mountain of data that implicates vaccines today. Wakefield a charlatan? Not proven... Did Wakefield say vaccines cause autism? No... Did The Lancet retract the publication because Wakefield said vaccines cause autism? No...
According to The Lancet they retracted the paper because of two factors. "..the claims in the original paper that children were 'consecutively referred' and that investigations were 'approved' by the local ethics committee have been proven to be false" (The Lancet, 2010). In an appeal to the UK High Court both of these charges by the British Medical Council were overturned. Mr. Justice Mitting criticized the U.K. General Medical Council, stating its judgment had been "based on inadequate and superficial reasoning" (High Court Of Justice, 2010). Wakefield's colleague Professor John Walder-Smith who had his medical credentials reinstated and name cleared filed the appeal. The charges and repercussions of Walker-Smith and Wakefield were identical. The claims of the BMC were deemed false to which they did not appeal this decision.
If you would bother to read the wrongly retracted paper you would find that Wakefield never claimed vaccines caused autism. He only mentioned that there were parental accounts that the children regressed after the MMR vaccine. He also encouraged the use of vaccination. His paper (not study) showed through pathology that the measles virus was demonstrated upon biopsy of ulcerate bowl tissue samples. This is not contested, or proven false. Here is the exonerated Dr. Walker Smith explaining the findings;
"We haven't done anything to demonstrate that the measles virus is causing autism or even causing bowel disease. We have simply shown that there is measles virus in the guts of a large number of children who have regressive autism" (Mahoney, 2006).
Adams et al. (2013). Toxicological status of children with autism vs. neurotypical children and the association with autism severity. Biological Trace Element Research. Retrieved from http://link.springer.com/article/10.1007%2Fs12011-012-9551-1
Bradstreet et al. (2004). Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of Children with Regressive Autism: A Report of Three Cases. Journal of American Physicians and Surgeons. Retrieved from http://www.jpands.org/vol9no2/bradstreet.pdf
Frye et al. (2013). Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Translational Psychiatry. Retrieved from http://www.nature.com/tp/journal/v3/n1/full/tp2012143a.html
Goldman et al. (2012). Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010). Human & Experimental Toxicology. Retrieved from http://het.sagepub.com/content/31/10/1012.full
High Court Of Justice. (2010). Professor John Walker-Smith and General Medical Council. Royal Courts of Justice. Retrieved from http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html
Li Z et al. (2010). Mitochondrial pathway leading to programmed cell death induced by aluminum phytotoxicity in Arabidopsis. Plant Signal Behav. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21512328
Mahoney, D. (2006). Data linking autism, measles virus in intestines viewed as preliminary. Clinical Psychiatry News. Retrieved from http://www.clinicalpsychiatrynews.com/news/childadolescent-psychiatry/single-article/data-linking-autism-measles-virus-in-intestines-viewed-as-preliminary/aaf5651a48.html
Rose et al. (2012). Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Translational Psychiatry. Retrieved from http://www.nature.com/tp/journal/v2/n7/full/tp201261a.html
The Lancet. (2010). Retraction-IIeal0lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. The Lancet. Retrieved from http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960175-4/fulltext
Zhang et al. (1989). Inhibition by aluminum hydroxide of the voltage-dependent closure of the mitochondrial channel, VDAC. Biochim Biophys Acta. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2469483