Casework File: When will we have a vaccinated verse unvaccinated study looking at total health outcomes as described by the Centers for Disease Control and Prevention's Immunizations Safety Office Scientific Agenda in February 2011 (CDC, page 44)?
Casework File: Why isn't the HHS offering General Pediatricians knowledge and training on how to better pre-screen their patients for mitochondrial disease (MD), which is associated with the prevalence of autism and increased risk of vaccine adverse events?
According to the government expert witness in the Hannah Poling case, Dr. Andrew Zimmerman, M.D. Pediatric Neurologist, "The cause for regressive encephalopathy in Hannah at age 19 months was underlying mitochondrial dysfunction, exacerbated by vaccine-induced fever and immune stimulation that exceeded metabolic energy reserves. This acute expenditure of metabolic reserves led to the permanent irreversible brain injury. Thus, if not for this event, Hannah might have led a normal full productive life. Presently, I predict Hannah will have a normal lifespan but with significant lifelong disability" (Zimmerman, 2007).
The known associated prevalence of MD and autistics...
"Autism spectrum disorder (ASD) has been associated with mitochondrial disease (MD). Interestingly, most individuals with ASD and MD do not have a specific genetic mutation to explain the MD, raising the possibility of that MD may be acquired, at leaset in a subgroup of children with ASD" (Frye et al, 2013).
Autism now effect 1:50 children, 1:30 boys. HHS could do a better job at protecting this pediatric population by initiating pre-screening protocols thereby avoiding a brain injury pattern resulting in autism symptomatology.
Casework File: Why is not looking at vaccine triggered cell-mediated immunity part of the safety analysis protocal by the United States Department of Health and Human Services (HHS) and carried out by the pharmaceutical industry. Why is it that when conducting vaccine safety and efficiency data HHS is satisfied with the simplistic measurement of humoral immunity? In essence in human trials the pharmaceutical industry sends the patients home with a diary card to document anecdotal adverse events and draw blood for antibody response.
We know that vaccines elicit powerful immune responses for that is their design. Why are we not measuring vaccine triggered cell-mediated immunity? "Microglia cells have receptors that enable them to sense damaged tissue and to recognize viruses, environmental and endogenous toxins, and other pathogens. Such recognition leads to upregulation (activation) of microglia cells" (Block et al, 2007).
This is what I find disturbing and what is clear in the study of neuroscience; "However, persistent activation of microglia has damaging effects and is thought to contribute to the neurodegeneration that occurs in Alzheimer's disease, Parkinson's disease, HIV encephalopathy, and other conditions. Microglia activation also develops progressively with advancing age in absence of stimulation" (Block at el, 2007).
So I would ask the HHS why are thy ignoring one arm of the immune response? Brain inflammation is a known association with patients with autism according to a recent cadaver study comparing autistics with non-autistic brains. Excerpt; "together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in autism brains may have functional consequence in terms of chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage" (Rose et al, 2012).
Congressional follow-up will be posted...