The most up-to-date and comprehensive source for studies on fluoride's systemic, multifaceted effects on human health, with 80+ years of research organized by health category, type of study, and date.
In many areas of the world, hypothyroidism is a major health concern and in addition to other factors—such as iodine deficiency—fluoride exposure should be considered as a contributing factor. The findings of the study raise particular concerns about the validity of community fluoridation as a safe public health measure.
Fluoride further declined the remaining renal function of the CKD animals, an effect that most likely overwhelmed the positive effect of fluoride on calcification in vitro. Ultrastructural analysis revealed that fluoride did not modify the Ca/P atomic ratio, but it was incorporated into the lattice of in vivo deposits. Fluoride also converted the crystallization pattern from plate to rode-like structures. In conclusion, while fluoride prevents calcification in vitro, the WHO's recommended concentrations in drinking water become nephrotoxic to CKD rats, thereby aggravating renal disease and making media vascular calcification significant.
Finally, we emphasise that the total number of neurotoxic substances now recognised almost certainly represents an underestimate of the true number of developmental neurotoxicants that have been released into the global environment. Our very great concern is that children worldwide are being exposed to unrecognised toxic chemicals that are silently eroding intelligence, disrupting
behaviours, truncating future achievements, and damaging societies, perhaps most seriously in developing countries. A new framework of action is needed.
Manganese is found in infant formula, cereals, drinking water etc (EPA, 2007). Here is what the Environmental Working Group has to say about Manganese and infant formula...
There are unresolved concerns about the safety of manganese found in baby formula. Manganese is a neurotoxic chemical found in much higher concentrations in infant formula than in mother’s milk. In fact, soy-based formulas contain about 80 times more manganese than breast milk, and formulas made with animal protein about 30 times more. Studies conducted as early as the 1970s and 80s show an association between various learning or behavior problems and elevated manganese levels.  Infants are not able to absorb and excrete excess manganese during their first year of life, a period of rapid development. Developmental deficits have been reported in primates fed 50 to 100 ounces of Isomil per day.  (Environmental Working Group, 2003)