I have wanted to study the methylation cycle for some time, and as you can see below how intimidating it is at first glance! There are specific key words we hear in autism research, and supplementation protocols that come out of defects in this cycle. We are told by our obstetricians and gynecologists to take prenatal vitamins that specifically contain folic acid, because they claim this will increase neurodevelopment, and one study demonstrated a decrease in autism (Schmidt et al., 2011). However, folic acid prenatal fortification increases the prevalence of MTHFR genetic defects, which might be the trigger of autism (Rogers, E., 2008). Then to further complicate things there has been confusion over the terms Folinic versus Folic Acid, or what supplement to take if the system is broken. All that said, let's work though two phases of the cycle, look at the science and try to find some clarity.